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Clear-cell sarcoma (formerly known as malignant melanoma of the soft parts) is a rare form of cancer called sarcoma. It is known to occur mainly in the soft tissues and dermis. Rare forms were thought to occur in the gastrointestinal tract before they were discovered to be different and redesignated as GNET. Recurrence is common. It has been associated with both EWSR1-ATF1 and EWSR1-CREB1 fusion transcripts. Clear cell sarcoma of the soft tissues in adults is not related to the pediatric tumor known as clear cell sarcoma of the kidney.〔Poppe B, Forsyth R, Dhaene K, Speleman F. ( Soft tissue tumors: Clear cell sarcoma. ) Atlas Genet Cytogenet Oncol Haematol. November 2002.〕 ==Pathology== Despite the name clear cell sarcoma, the tumor cells do not necessarily need to have clear cytoplasm. The lesion has a distincly nested growth pattern with a mixture of spindle, epithelioid and tumor giant cells. Approximately two thirds of the tumors contain melanin pigment. Clear cell sarcoma, similar to melanoma, has consistent positivity for S-100, HMB-45, and MITF. 〔(【引用サイトリンク】url=http://pathologyoutlines.com/topic/softtissueclearcellsarcoma.html )〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Clear-cell sarcoma」の詳細全文を読む スポンサード リンク
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